In her former life, she was known as Belladonna Vetrano, an Arachnos Night Widow with an affinity for stealth and infiltration. That life ended while on a strike mission when Vetrano's entire crew was killed in an ambush. Instead of passing to the spirit world, Belladonna's vengeful ghost lingered on the mortal plane until Arachnos Mystics bound her spirit, now known as Ghost Widow, to Arachnos, allowing her to remain on Earth and serve the organization as long as it existed.
When she learned that the Statesman, Arachnos' greatest threat was alive, Ghost Widow set out to find how he had returned from death without her knowledge. Even though he turned out to be Tyrant, his new willingness to defend others meant Arachnos was under threat once again. Ghost Widow tracked him down to the alternate, Synd-occupied Earth and set her trap.
As the two battled, an army of Atlas drones attacked. Their differences set aside for a moment, the two fought through the onslaught, leaving only scrap in their wake. Tyrant explained to Ghost Widow that the threat of Atlas was not confined to only one Earth and how Masters from different worlds and dimensions had already joined the battle against it. The cloning of Master Jinsoyun was of particular interest and Ghost Widow's desire to live again sealed her decision.
She reported back to Lord Recluse of an advanced civilization brought to its knees, and her concern that Arachnos' survival, and thus her own, would one day be at risk unless Atlas was destroyed. She insisted that she personally lead the fight on behalf of Arachnos and promised to bring Atlas' vast knowledge to her Lord once the enemy had fallen. However, Ghost Widow had more selfish and personal plans for that knowledge.